Falciparum malaria associated with jaundice, renal failure and anaemia

Abstract Three patients were described in whom falciparum malaria was accompanied by severe jaundice, renal failure due to tubular necrosis, and anaemia without overt intravascular haemolysis. Treatment with antimalarial drugs and peritoneal dialysis was successful in 2, but the third patient died from a bleeding peptic ulcer which complicated his illness. The renal failure and other manifestations of the P. falciparum infection are considered in the light of a common toxic factor.