Wildlife Toxicity Assessment for Thiodiglycol

Thiodiglycol (TDG) is used commercially as a solvent in antifreeze solutions, dyestuffs for printing, and as part of the process by which polyvinyl chloride is manufactured. It is also either a starting material or a precursor in the production of the chemical warfare agent sulfur mustard. TDG toxicity data for birds, amphibians, and reptiles were lacking. For mammals, acute, subacute, and subchronic studies were available representing two species in two orders. Adverse effects of TDG include reduced body weight, as well as increased kidney weight, increased urine output, and decreased urine pH, which may indicate functional deficits in the kidney. Reproductive and developmental effects were observed in one species representing one order and include decreased maternal and fetal body weight and decreased maternal food consumption. No and low observed adverse effect levels (NOAEL and LOAEL) of TDG for mammals of 129 mg/kg/day and 387 mg/kg/day respectively, were developed. The sole inhalation study suggests exposures of 5.4 mg/L TDG or less are not likely toxic. Dermal studies gave sufficient data for TRV development resulting in a NOAEL of 118 mg/kg and a LOAEL of 1,180 mg/kg.