Tumor vaccine therapy for melanoma: review of literature

The phenomenon of tumor spontaneous regression of many patients with melanoma makes re-searchers pay much attention to the innate immunogenicity of melanoma.It's also supported by serveral manifestations of histo- logical observation, Correspondingly, patients with Breast Medullary Carcinoma or skin Maligant Melanoma who have an infiltration of lymphocytes get better prognosis. Moreover.it' s demonstrated that cytokines play an important role in such regulation of antitumor im- munological reponse. All above imply that there is active anti- tumor immunological response in the body and en- lighten researchers to innitiate a series of studies on tumor vaccine using the melanoma as a theraputic mod- el. This article reviews the tumor vaccine therapy for melanoma on the advantage and disadvantage of its main types and relative clinicalo trials. Key words: Cancer vaccine;  Melanoma