MP32-19 ADJUVANT CHEMOTHERAPY VERSUS OBSERVATION AFTER RADICAL CYSTECTOMY FOR PATIENTS WITH NODE-POSITIVE BLADDER CANCER

INTRODUCTION AND OBJECTIVES:This study aimed to compare adjuvant chemotherapy (AC) versus observation after radical cystectomy in patients with pathologically node-positive bladder cancer (pN+). We also attempted to identify pN+ patients most likely to benefit from AC after RC.METHODS:Outcomes were reviewed in patients with pTanyN1-3M0 bladder cancer treated with RC between January 1995 and June 2017. Patients who underwent RC alone were assigned to the RC group and those who received AC were assigned to the AC group. Baseline characteristics between two groups were controlled with inverse probability of treatment weighting (IPTW)-adjusted analyses. Variables prognostic for survival were assessed by stratified time-varying covariate Cox model.RESULTS:Of 281 enrolled patients, 122 (43.4%) underwent RC alone and 159 (56.6%) received AC. The 3-year IPTW-adjusted rates of metastasis-free survival was similar between AC and RC groups (35.8% vs. 31.2%, p=0.471), whereas IPTW-adjusted overall survival rate was h...