Sclerosing angiomatoid nodular transformation of the spleen - a case report

Sclerosing angiomatoid nodular transformation of the spleen (SANT) is a rare, relatively new, and benign splenic lesion, which mostly affects middle-aged females. It is characterized by multiple angiomatoid nodules in fibrosclerotic stroma comprising myofibroblasts and infiltrating chronic inflammatory cells. The etiology is unknown. The diagnosis is based on the histopathologic examination of the splenectomy specimen. We report a classic case of SANT in a 52-year-old woman with abdominal discomfort and mild splenomegaly. The immunohistochemical profile and updated clinicopathological data of the disease are discussed.