Experimental Analysis of Cellular Membrane Mechanical Properties

The study of cell-environment can reveal the possibilities of using nanoparticles in biomedicine. The condition of the cell membrane reflects the mood of whole cell. The membranes as the outer envelope of the cell have a semi-fluid character, and the proteins and lipid molecules are in constant motion. Our aim is to develop methodology for measuring of cell mechanical properties. Atomic force microscopy and force spectroscopy were selected for contact between a tip of cantilever and a cell. This work presents the results of comparison using different tips of cantilevers and verification on several types of cells. Dependence between Young’s modulus of a cell membrane and surface attachment is next part of this work. Different surfaces are creating by coating of glass. Working with living cells claims specific approach in all parts of the research. The results compare the properties of the same cells on different surfaces.