Detection of COX-2 in Squamous Cell Carcinoma

Objective To investigate the significance and relationship of cyclooxygenase-2 (COX-2) and Ki67 in the pathogenesis and development of squamous cell carcinoma (SCC).Methods Specimens from 57 SCC patients and 6 normal persons were assayed for COX-2 and Ki67 using immunohistochemistry.Results ①No COX-2 and Ki67 in normal specimens was detected,but it was significantly increased in SCC(P0.05).②The COX-2 showed no correlated with the tumor differentiation in SCC (P=0.756),but Ki67 was significantly different in SCC of different histological grade(P=0.002).③ COX-2 was positive correlated with Ki67 (P=0.05).Conclusion The abnormal level of COX-2 and Ki67 plays a role in carcinogenesis and development of SCC, the over-expression of COX-2 may result in the proliferation of tumor cells.