Styrene-butadiene Block-copolymers Used as Immobilization Support for Drugs with Prolonged Antibiotic Effect

The paper presents a study about obtaining materials with prolonged biocidal effect based on styrenebutadiene block-copolymers (SBS) grafted with methacrylic acid (ACM) and coupled with antibiotics from the ampicillin group. The IR spectroscopy and the elemental analysis were used to confirm the structure of SBS block-copolymers grafted with methacrylic acid and of the medical ones. The content of grafted methacrylic acid was about 18.8 % in accordance with the 1,2 enchained butadiene content, proving that the methacrylation polymer-analogous reaction takes place at these pendant vinyl groups of the polybutadiene chain. The concentration of the methacrylic acid-ampicillin pendant group is about 38 % and corresponds to the theoretical calculated one. The antibacterial testing of the synthesized polymers showed that the final reaction product has a relatively high biocidal activity on gram-positive and gram-negative microorganisms.