Modic changes in the cervical spine
2012
We conducted a prospective follow-up MRI study
of originally asymptomatic healthy subjects to clarify the development
of Modic changes in the cervical spine over a ten-year period and
to identify related factors. Previously, 497 asymptomatic healthy
volunteers with no history of cervical trauma or surgery underwent
MRI. Of these, 223 underwent a second MRI at a mean follow-up of
11.6 years (10 to 12.7). These 223 subjects comprised 133 men and 100
women with a mean age at second MRI of 50.5 years (23 to 83). Modic
changes were classified as not present and types 1 to 3. Changes
in Modic types over time and relationships between Modic changes
and progression of degeneration of the disc or clinical symptoms
were evaluated. A total of 31 subjects (13.9%) showed Modic changes at
follow-up: type 1 in nine, type 2 in 18, type 3 in two, and types 1
and 2 in two. Modic changes at follow-up were significantly associated
with numbness or pain in the arm, but not with neck pain or shoulder
stiffness. Age (≥ 40 years), gender (male), and pre-existing disc
degeneration were significantly associated with newly developed
Modic changes. In the cervical spine over a ten-year period , type
2 Modic changes developed most frequently. Newly developed Modic
changes were significantly associated with age, gender, and pre-existing
disc degeneration.
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