A274 IMPACT OF FIT CUT-OFFS VALUES ON MISSED COLORECTAL CANCER AND HIGH-RISK LESIONS

Background Colorectal cancer (CRC) is the third most common cancer worldwide and carries a high mortality rate. Early screening has decreased morbidity and mortality from CRC. The fecal immunochemical test (FIT) uses antibodies against human hemoglobin and gives a quantitative value depending on the amount of hemoglobin detected in stool samples. The FIT is used in Canada as the standard for CRC screening of average risk populations. A lower numerical FIT is more sensitive for detecting “high-risk” lesions (HRL) but increases the number of colonoscopies that are performed; therefore, adjusting the positive value threshold allows screening programs to change the sensitivity and specificity of the test for detecting HRL and CRC