Extranodal non-Hodgkin’s lymphoma: A case series at a tertiary care hospital

Objective: To study histopathological and clinicopathological findings in a case series of Extra Nodal Non Hodgkin Lymphomas (EN NHL). Materials and Methods: 17 cases of primary ENNHLs, collected during a period of November 2019 to November 2020 (one year), wherein the clinical data included age, gender, site, clinical presentation and radiological findings were collected. Haematoxylin and eosin staining was done along with Immunohistochemistry (IHC) using a panel of antibodies depending on the morphology. Result: 17 cases of primary ENNHLs taken. Majority of our patients were from higher age group, presenting in sixth decade, though the age range was wide between 5-92 years. Our study included 12 males and 5 females, with a male: female ratio of 2.4:1. We found retroperitoneal masses and GIT as the most common site for ENNHLs.Weight loss followed by fever was the most common clinical presentation in our study presentation. Ann Arbor Staging was done in 16/17 cases where 35% (6/17) belonged to stage I, 35% (6/17) cases belonged to stage II, 17.6 (3/17) belonged to stage III and 1.5% (1/17) belonged to stageIV. Eastern cooperative oncology group performance scale (ECOG) was also calculated and documented. Conclusion: This study highlights importance of diagnosing Extranodal NonHodgkin’s lymphomas as a separate entity since its clinical presentation, prognosis, staging and management differs from Nodal NonHodgkins lymphoma. Keywords: Immunohistochemistry, Extranodal, NonHodgkin lymphoma.