Prevalence of allergic contact dermatitis caused by hydroxyisohexyl 3-cyclohexene carboxaldehyde has not changed in Denmark

detergents; hydroxyisohexyl-3-cyclohexene carboxaldehyde; irritant contact dermatitis; cosmetics.Hydroxyisohexyl 3-cyclohexene carboxaldehyde (HICC)is a fragrance ingredient that is often used in cosmeticproducts (1, 2). Because of this frequent use in cosmeticproducts, as well as its use in higher concentrationsthan the recommended safe-use concentration, HICCis one of the most frequent causes of allergic contactdermatitis (3–10). In order to reduce the prevalenceof contact allergy to HICC, the International Fragrance