Mood in Irritable Bowel Syndrome Patients and Correlation with SPECT Cerebral Blood Flow Perfusion

Objective The mood change and its related factors were analyzed in patients with Irritable bowel syndrome(IBS)to study its possible pathophysiological mechanism.Metheds Mood changes were assessed with Self-Rating Depression Scale(SDS)for depression and Self-Rating Anxiety Scale(SAS)for anxiety in 50 patients with hyperthyroidism and 50 healthy controls.EPQ questionair was used to get personallty traits for both patients and controls.The correlations were done between SDS,SAS scores and regional cerebral blood flow perfusion(rCBF)of person.Results 76 percent of the patients had depression and 46% had anxiety,and the difference was significant(P0.05).There were negative correlations between scores of depression and rCBF in left claunstrum,left 1entiform,right rectus gyrus and right uncus;and negative correlation between scores of depression and rCBF in left cuneus,bilateral precuneus,left superior occipital gyrus,right superior marginal gyrus and right inferior parietal lobe.Regional cerebral blood flow in left lentiform and 1eft insula were negatively correlated with of anxiety.Conclusion Depression and anxiety are found in patients with IBS.Abnormal cerebral blood flow perfusion might be one of the possible mechanisms in mood disorder.