A Rhodium(I)-Catalyzed Demethylation—Cyclization of o-Anisole-Substituted Ynamides in the Synthesis of Chiral 2-Amido Benzofurans.

Jossian Oppenheimer,Whitney L. Johnson,Michael R. Tracey,Richard P. Hsung,Pei‐Yuan Yao,Renhe Liu,Kang Zhao

A Rhodium(I)-Catalyzed Demethylation—Cyclization of o-Anisole-Substituted Ynamides in the Synthesis of Chiral 2-Amido Benzofurans.

2007

Jossian Oppenheimer
Whitney L. Johnson
Michael R. Tracey
Richard P. Hsung
Pei‐Yuan Yao
Renhe Liu
Kang Zhao

A Rh(I)-catalyzed demethylation−cyclization sequence for a direct transformation of o-anisole-substituted ynamides to benzofurans is described here. The Ag salt functions synergistically with Rh(I) for the key demethylation step.

Keywords:

Rhodium
Anisole
Demethylation
Chemistry
Organic chemistry
Chirality (chemistry)
Catalysis

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