Reactions of Pd(PPh3)4 with 3‘,5‘-Di-O-acetylthymidine: Oxidative Addition of Pd(PPh3)4 on Thymidine N3 and C4 Atoms

Oxidative addition reactions of Pd(PPh3)4 on the pyrimidine nucleosides 3‘,5‘-di-O-acetylthymidine and 3‘,5‘-di-O-acetyl-4-chlorothymidine and on the nucleobase 1-methylthymine have been investigated. N3 and C4 metal coordinated complexes 3 and 7 were isolated and characterized by spectroscopic techniques. Moreover, the crystal structure of the trans-[PdCl(1-methyl thymine)(PPh3)2]·H2O (4) is reported.