Assessment of oxidative stress markers and level of antioxidant in preeclampsia

Introduction: In pre-eclampsia the pathophysiology is still under investigation. Lipid peroxidation is important for the normal endothelial cell function. The antioxidant like Vitamin E and vitamin C play a role in preventing preeclampsia. Materials and Methods: We compare between serum malondialdehyde (MDA) level, a product of lipid peroxide and the antioxidant (vitamin C and E) in pregnant women with or without preeclampsia. Patient are divided to two group; Group 1 (n=50): pregnant women between 28 and 40 weeks’ gestation with preeclampsia and Group 2(n=50): the control group includes pregnant women without hypertension episode during their pregnancy. Result: Serum MDA levels were raised in women with preeclampsia compared with normal pregnancy (P blood pressure in preeclamptic and normal pregnancies (rs = 0.693, p respectively. Vitamin C, E level show s highly significant decrease in Pre-eclamptic women than normal one (p pressure and diastolic blood pressure (P between vitamin E level (mg/dl) and both systolic blood pressure and diastolic blood pressure (P (P Conclusion: These results provide further evidence that excessive lipid peroxidation level and decreases in vitamin E and C levels (which are responsible from antioxidant activity) may contribute to the pathophysiology and pathogenesis of preeclampsia. Keywords: Preeclampsia, Lipid peroxidation, Vitamin E and vitamin C.