ASPIRIN, A NON-STEROIDAL ANTI-INFLAMMATORY DRUG INDUCES CYTOTOXICITY AND ARRESTS ANGIOGENESIS IN LN229 GLIOMA CELLS

Glioblastoma is a devastating cancer of the brain with fatal prognosis. It is a highly vascularised cancer due to the presence of angiogenic factors. In the present study, we investigated the anticancer effect of aspirin in LN229 glioma cell line by inhibiting critical angiogenic markers HIF-1α and VEGF. A dose dependent treatment of aspirin revealed a decrease in the markers HIF-1α and VEGF, which demonstrates that aspirin might arrest angiogenic ability of the LN229 cells. This study features the promising effect of aspirin for a potential therapeutic option in future.