Влияние экстракта Calendula officinalis на антиоксидантный и энергетический статус печени при экспериментальном гепатите

The hepatoprotective effect of Calendula officinalis L. extract was studied on the experimental model of acute toxic hepatitis induced by administration of CCl 4 in rats. Administration of the C. officinalis extract in a dose of 100 mg/kg (p.o.) for 13 days decreased the severity of oxidative stress by increasing the activity of key enzymes (catalase, SOD, GSH). The phytopreparation increased the activity of hepatocytic enzymes as glutathione peroxidase by 15% ( p < 0.05) and glutathione reductase by 39% in the rat liver tissue (relative to control) as well as reduced the content of malondialdehyde by 28% ( p < 0.05). It was also found that the extract of C. officinalis positively influenced the energy metabolism in hepatocytes as manifested by increasing the ATP content by 28% ( p < 0.05), decreasing lactate level by 31% ( p < 0.05), and normalizing lactate/pyruvate ratio in the liver tissue of rats with experimental toxic hepatitis. The obtained results allow the proposed extract of C. officinalis to be recommended for further investigation as a promising plant hepatoprotector.