Abstract 104: The Use of Nitrated apolipoprotein A1 (NT-ApoA1) to Predict Mortality in Patients with Known or Suspected Coronary Artery Disease

Background: Studies have suggested that nitrated apolipoprotein A1 (NT-apoA1) levels may be associated with coronary artery disease (CAD). We therefore hypothesized that NT-apoA1 might be associated with the prediction of all-cause mortality in CAD patients. Methods: Using an ELISA, we measured plasma NT-apoA1 levels in 236 patients with known or suspected coronary artery disease (CAD) undergoing coronary angiography. The patients were then followed prospectively for the development of all-cause mortality for up to 7 years. Results: Lower NT-apoA1 levels were associated with worse renal function, lower HDL levels, higher triglyceride levels and lower ejection fraction. There was positive correlation between NT-apoA1 and HDL cholesterol levels (correlation coefficient 0.366; p <0.0001). After adjustment for a variety of baseline clinical, angiographic and laboratory parameters, log plasma NT-ApoA1 levels were an independent predictor of all-cause mortality [HR, 0.279; 95% CI, 0.084-0.922; p=0.036]. Further...