Structure-activity relationship of triaryl propionic acid analogues on the human EP3 prostanoid receptor.

Abstract Potent and selective ligands for the human EP 3 prostanoid receptor are described. Triaryl compounds bearing an ortho -substituted propionic acid moiety were identified as potent EP 3 antagonists based on the SAR described herein. The binding affinities of key compound on all eight human prostanoid receptors is reported.