737-P: Efficacy and Safety of Insulin Glargine 300 U/mL (Gla-300) in People with Type 2 Diabetes Mellitus (T2DM) Uncontrolled on Basal Insulins (BI): ARTEMIS-DM Study

Background: The efficacy and safety of switching to Gla-300 in T2DM uncontrolled on BI has been demonstrated in RCTs and RWE studies in the US and EU. However, similar data in wider geographic regions are limited. ARTEMIS-DM is a multicentre, interventional, single-arm, Phase IV study aimed to evaluate the impact of this switch in 14 countries across Asia, Middle East - Africa and Latin America. Methods: ARTEMIS-DM study enrolled participants with HbA1c between 7.5 and 10%. Primary endpoint was change in HbA1c from baseline to 26 weeks. Results: Of 372 participants (50% male), the mean (SD) age was 60.9 (10.0) years and BMI was 29.57 (5.43) kg/m2. Majority of participants (62.6%) were Conclusion: In people with T2DM uncontrolled on previous BI, switching to Gla-300 with optimal titration was associated with improved glycemic control and low incidence of hypoglycemia. Disclosure B. Sethi: None. K. Alrubeaan: None. M. Unubol: None. M. N. Mabunay: Employee; Self; Sanofi, Stock/Shareholder; Self; Sanofi. M. Naqvi: Employee; Self; Sanofi, Stock/Shareholder; Self; Sanofi. B. Berthou: None. V. Pilorget: Employee; Self; Sanofi. G. Frechtel: None. Funding Sanofi