ACUTE AND SUB ACUTE TOXICITY STUDY ON SIDDHA DRUG NERUNJIL VITHAI CHOORANAM (NVC)
2014
The polyherbal formulation Nerunjil vithai chooranam (NVC) has been used for the treatment of Male infertilit y (MI). As a mandate, steps were taken to evaluate safety p rofile of NVC in rats following OECD guidelines. In acute oral toxicity study, a single dose of NVC was administered and observed for 14 days. In acute to xicity studies, NVC revealed no abnormal signs upto the dose level of 2000mg/kg body weight. Sub-acute toxici ty studies were carried in four different groups in wh ich NVC was administrated orally to rats once daily for 28 days in various doses ranging from 36, 180,360 mg/kg for rat respectively. Detailed hematological, biochemi cal, necropsy and histopathological evaluation of organs was performed for all animals. The NVC was well tolerated and no toxic manifestations were seen in any animal . Histopathological analysis revealed that Spleen, Testes, Pancreas, Lung, Intestine, Stomach, Liver, Brain, H eart, Ovary, Uterus and Kidney tissues of treated g roups did not show any signs of toxicity. No toxic effect was observed in acute and sub-acute toxicity studies o f Nerunjil vithai chooranam.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
6
References
0
Citations
NaN
KQI