Identification and characterization of a potential ischemia-selective N-methyl-D-aspartate (NMDA) receptor ion-channel blocker, CNS 5788.

Abstract The identification and characterization of a potentially ischemia-selective and orally-active sulfoxide based NMDA ion-channel blocker showing good neuroprotective activity, ( R )-(+)- N -(2-chloro-5-methylthiophenyl)- N ′-(3-methylsulfinylphenyl)- N ′-methylguanidine (CNS 5788), is described.