Эндотелиальная дисфункция у больных ревматического профиля

Aim — to investigate the relationship between indicators of endothelium activation and markers of inflammatory activity in rheumatic patients.. The study involved 112 patients including 34 with systemic lupus erythematosus (SLE) and 78 with rheumatoid arthritis (RA) aged from 19 to 62 years. The markers of endothelium activation, indices of inflammatory activity and correlation between them were investigated. Patients with RA and SLE exhibited disturbed endothelial function, increased level of soluble vascular cell adhesion molecule-1 (sVCAM-1) and von WIllebrand factor antigen (Ag: vW), desquamated endotheliocytes (DE) in comparison with control (р<0,01). Interleukin-8 (IL-8) levels in RA and SLE were significantly higher than in a control: 412,8 pg/ml, 331,1 pg/ml, 208 pg/ml respectively (p < 0,01). Significant positive correlation between RA and SLE activity scores (estimated from DAS28 and SLAM/SLEDAI respectively) and markers of endothelial dysfunction (sVCAM-1, Ag: vW, DE) was documented. Correlation coefficients were R = 0,82, 0,80 and 0,85 respectively, p < 0,01 for RA patients; R = 0,64, 0,69 and 0,61, p < 0,01 for SLE patients (SLAM); Spirmen’s coefficients 0,64, 0,53 and 0,81, p < 0,01 for SLE patients (SLEDAI). Levels of endothelial dysfunction markers in RA and SLE patients increased with increasing indices of inflammatory activity. Increased levels of IL-8, sVCAM-1, Ag: vW, DE in patients with RA and SLE lead to the damage of endothelium.