An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ

Alexander S. Banks,Fiona E. McAllister,João-Paulo G. Camporez,Peter-James H. Zushin,Michael J. Jurczak,Dina Laznik-Bogoslavski,Gerald I. Shulman,Steven P. Gygi,Bruce M. Spiegelman

An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ

2015

Alexander S. Banks
Fiona E. McAllister
João-Paulo G. Camporez
Peter-James H. Zushin
Michael J. Jurczak
Dina Laznik-Bogoslavski
Gerald I. Shulman
Steven P. Gygi
Bruce M. Spiegelman

Blocking ERK/MAP kinases improves insulin sensitivity thorough a mechanism similar to the actions of the anti-diabetic thiazolidinediones drugs on PPARγ.

Keywords:

Cyclin-dependent kinase 5
Insulin resistance
Insulin
Cancer research
MAPK/ERK pathway
Phosphorylation
Kinase
Peroxisome proliferator-activated receptor
Adipose tissue
Biology
Mitogen-activated protein kinase
Chemistry

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