Association of Long Non-Coding RNA MEG3 Polymorphisms and Risk of Prostate Cancer in Chinese Han Population.

Purpose: To explore the association between MEG3 polymorphisms and the risk of prostate cancer in Chinese Han population. Materials and Methods: Two MEG3 single-nucleotide polymorphisms (SNPs) (rs11627993 C>T rs7158663 A>G) were genotyped in a case-control study which 165 prostate cancer patients and 200 healthy controls were recruited by a Real-Time Polymerase Chain Reaction (PCR) with the TaqMan assay. The odds ratios (ORs) and 95% confidence intervals (CIs) was used to estimate the strength of association. Results: No statistically significant differences were found in the allele or genotype distributions of the MEG3 rs11627993 C>T and rs7158663 A>G polymorphisms among cases or healthy control subjects (rs11627993: CC vs CA: 95% CI = 0.54-1.95，ORs = 1.03; CC vs AA: 95% CI = 0.67-2.54，ORs = 1.30 ; CC/CA vs AA: 95% CI = 0.81-1.98，ORs = 1.26 , P = .29 ; C vs A: 95% CI = 0.85-1.57，ORs = 1.16，P = .35; rs7158663: AA vs AG: 95% CI = 0.76-5.08，ORs = 1.97, AA vs GG: 95% CI = 0.57-3.29，ORs = 1.37; AA/AG vs GG : 95% CI = 0.56-1.32，ORs = 0.86，P = .49; A vs G: 95% CI = 0.69-1.39，ORs = 0.98, P = .91) Further stratified analysis detected no significant association, either. Conclusion: The MEG3 polymorphisms (rs11627993 C>T and rs7158663 A>G) may have no influence on the susceptibility of the prostate cancer. More potentially functionally polymorphisms in MEG3 need to be studied in a larger series.