Spleen Transplantation Model

The advent of rapidly accelerated experience in experimental spleen transplantation models gives a hope for discovery the “Holly Grail” of transplantation tolerance. Successful spleen allotransplantations in rodents can lead to specific donor tolerance induction. Previous studies on large animal model without knowledge of major histocompatibility complex jeopardized on extinction of this idea. The reprisal of spleen allotransplantation was triggered by rapid immunology development. In this chapter we tried to describe methods of spleen transplantation and explain the new approach of spleen allograft tolerogenic effect.