Cyclooxygenase-1–Deficient Mice Have High Sleep-to-Wake Blood Pressure Ratios and Renal Vasoconstriction

We used cyclooxygenase-1 (COX-1)–deficient mice to test the hypothesis that COX-1 regulates blood pressure (BP) and renal hemodynamics. The awake time (AT) mean arterial pressures (MAPs) measured by telemetry were not different between COX-1 +/+ and COX-1 −/− (131±2 versus 126±3 mm Hg; NS). However, COX-1 −/− had higher sleep time (ST) MAP (93±1 versus 97±2 mm Hg; P P −/− had higher MAP (109±5 versus 124±4 mm Hg; P −1 · min −1 · g −1 ; P P −/− had a 89% reduction ( P 2 , a 76% reduction ( P 2 , a 40% reduction ( P 1α (6keto), a 27% reduction ( P 2α (11β), a 35% reduction ( P P +/+ (6.9±0.9 versus 3.2±0.6 g · g −1 creatinine · 10 −3 ; P −/− (5.1±0.9 versus 4.9±0.7 g · g −1 creatinine · 10 −3 ; NS). Urine collection during ST showed lower excretion of 6keto, 11β, NOx, aldosterone, sodium, and potassium than during AT in both COX-1 +/+ and COX-1 −/− , and there were positive correlations among these parameters (6keto versus NOx; P P P