Selenopheno[2,3-f]coumarins: a novel scaffold with antimetastatic activity against melanoma and breast cancer

General aim of the current research is to find novel non-toxic small molecules with antimetastatic activity. Herein we present series of novel selenopheno[2,3-f]coumarins with low cytotoxic profile against cancer cells with different nature (carcinomas, sarcomas, melanoma, neuroblastoma, and hepatoma). Based on SAR, few compounds selectively induce MMP inhibition and suppress angiogenesis in vivo up to 57% (10µM). Certain derivatives are excellent agents for in vivo prevention of melanoma and breast cancer metastasis: up to 97% with no visual side effects. The present study provides scientific evidence that selenophenocoumarin scaffold is a promising competitor for the development of drug candidates with metastasis-suppressing properties.