The effect of low-dose X-irradiation on numerical and structural chromosome anomaly induction in mouse immature oocytes
1990
Abstract The ability of low doses of X-rays to induce numerical and structural chromosome anomalies in immature oocytes was examined in two experiments. In the first, 10–11-day-old females were given 0.1 or 0.2 Gy of X-rays and sampled at intervals up to 32 weeks later. In the second, 4–5-week-old females were given 0.1 Gy of X-rays and sampled up to 36 weeks post-irradiation. Chromosome anomalies were assessed in metaphase II oocytes. In the first experiment, there was evidence of dose-related increase in both hyperhaploidy ( n + 1) and structural chromosome anomalies. In the second experiment, only the frequency of structural chromosome anomalies was found to increase consistently after irradiation. There was no indication that radiotion-induced depletion of the oocyte population was associated with an early onset of the maternal age effect on nondisjunction.
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