One-Step Three-Component Synthesis of New 2,5,6,7-Functionalized 5,8-Dihydropyrido-[2,3- d ]pyrimidin-4(3 H )-ones
2018
One-step three-component cyclocondensation of 2,6-disubstituted pyrimidin-4(3H)-ones with 1,3-dicarbonyl compounds and some aromatic and heterocyclic aldehydes on heating or under microwave irradiation afforded new functionally substituted 5,8-dihydropyrido[2,3-d]pyrimidin-4(3H)-ones. Conventional heating was found to be more advantageous. The effects of the 2-substituent in the initial pyrimidin-4(3H)-one and the nature of the dicarbonyl component on the product structure and yield were analyzed.
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