Sirtuin 6 and renal injury: another link in the β-catenin chain?

A protective role for sirtuin 6 (Sirt6) in the context of chronic renal injury is reported by Cai et al. in this issue of Kidney International. The mechanism is thought to be mediated by Sirt6's deacetylase activity, specifically on beta-catenin target genes. This commentary discusses these results and the interaction between Sirt6 and beta-catenin within the broader context of beta-catenin signaling and injury.