Clinical effects of platelet rich fibrin in prevention of bleeding and swelling after mandibular angle reduction

Objective To observe the clinical effect of platelet- rich fibrin (PRF) on prevention of postoperative hemorrhage and facial traumatic swelling in patients with mandibular angle osteotomy. Methods Twenty-five patients with mandibular angle hypertrophy were included in this study from January 2014 to November 2015. Split face comparative study was carried out to use the left and right sides as the experimental side and the control side, respectively. The PRF in the experimental side was placed in the mandibular osteotomy, while the control side was placed in platelet- poor plasma (PPP). After operation, the drainage volume and facial swelling degree were measured. Results The drainage volume of the experimental group (PRF group) was (20.35±7.40) ml, the control group (PPP group) was (43.23±11.96) ml, and the difference was statistically significant (P<0.05). There was no such case without swelling in postoperative third day. The facial swelling score on the experimental side was (1.19±0.40), the control side was (2.62±0.64), and two groups of postoperative facial swelling scores were significantly different (P<0.05). Conclusions The PRF can reduce postoperative bleeding and facial swelling after mandibular angle osteotomy. Key words: Mandibular angle reduction; Platelet- rich fibrin; Postoperative hemorrhage; Facial traumatic swelling