Повторный опыт агрессии и последствия депривации у самцов мышей

Smagin DA, Bondar NP, Kudryavtseva NN. [Repeated aggression and implications of deprivation in male mice]. Psychopharmacol Biol Narcol. 2010;10(1-2):2636-2648. Epub 06 November, 2010. Russian.BACKGROUND. Male mice with a long positive fighting history develop behavioral psychopathology, which includes abnormal aggression, pronounced anxiety, hyperactivity, stereotypic reactions, disturbances in social recognition etc. METHODS. Behavior of C57BL/6J male mice with 20 days experience of aggression was investigated before and after no-fight period (14 days) in elevated plus maze, open field, partition and agonistic interactions tests. RESULTS. It was shown that level of aggression was increased in 67 % of males and was decreased in 33 % of males after fighting deprivation. These two groups of animals differed initially in aggression levels before no-fight period: higher aggression level was in the males that decreased afterwards manifestation of aggression. However these males had no differences in many psychoemotional characteristics evaluated in elevated plus maze, open field and partition tests. CONCLUSION. Positive fighting experience affects subsequent agonistic behavior increasing aggressiveness in most part of male mice after fighting deprivation. It is supposed that brain opioidergic systems are involved in the effects of repeated aggression and deprivation effects. Date submitted: September 29, 2010; Accepted: November 06, 2010.Citation: Psychopharmacol Biol Narcol. 2010;10(1-2):2636-2648