Hyperimmune intravenous immunoglobulin containing high titers of pandemic H1N1 hemagglutinin and neuraminidase antibodies provides dose-dependent protection against lethal virus challenge in SCID mice

Christine Hohenadl,Walter Wodal,Astrid Kerschbaum,Richard Fritz,M. Keith Howard,Maria R. Farcet,Daniel Portsmouth,John Mcvey,Donald A. Baker,Hartmut J. Ehrlich,P. Noel Barrett,Thomas R. Kreil

Hyperimmune intravenous immunoglobulin containing high titers of pandemic H1N1 hemagglutinin and neuraminidase antibodies provides dose-dependent protection against lethal virus challenge in SCID mice

2014

Christine Hohenadl
Walter Wodal
Astrid Kerschbaum
Richard Fritz
M. Keith Howard
Maria R. Farcet
Daniel Portsmouth
John Mcvey
Donald A. Baker
Hartmut J. Ehrlich
P. Noel Barrett
Thomas R. Kreil

Background Convalescent plasma and fractionated immunoglobulins have been suggested as prophylactic or therapeutic interventions during an influenza pandemic.

Keywords:

Virology
Antibody
Neuraminidase
Pandemic
Neutralizing antibody
Virus
Hemagglutinin (influenza)
Titer
Biology
Immunology
Influenza A virus

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