Evaluation of carboplatin dosage based on a body surface area adjusted 4-variable modification of diet in renal disease (MDRD) equation

13524 Background: Calculations of carboplatin dose are based on the Calvert formula, which incorporates glomerular filtration rate (GFR). In everyday practice, creatinine clearance (CrCl) as calculated by Cockroft-Gault, Jelliffe or other formulas is commonly substituted for GFR in the Calvert formula. More recently, a new formula, originally devised by the MDRD research group for estimating GFR (eGFR), has been promulgated. In this study the impact of interchanging CrCl with eGFR when calculating carboplatin dose was investigated. Allied to this we highlight the importance of taking body surface area (BSA) into account when using eGFR, known as ‘absolute GFR’. Methods: We conducted a retrospective analysis of patients (pts) receiving carboplatin at our institution from December 2005 to October 2006. Serum creatinine and CrCl according to the Cockcroft-Gault and the Jelliffe formulas were recorded. Calvert formula derived carboplatin dose using the CrCl was compared to eGFR and absolute GFR. Results: 92 c...