Determination of 2-Aryl-7(3′,4′-Dialkoxyphenyl)-Pyrazolo [1,5-alpha] Pyrimidine, a Novel Phosphodiesterase-4 Inhibitor, in Rat Plasma by Liquid Chromatography–Tandem Mass Spectrometry

Kyeong-Ryoon Lee1, Jin Sook Song1, Yoon-Jee Chae2, Min-Sun Kim1, Sung-Heum Choi1, Dong Ju Jeon3, Myung Ae Bae1 and Sung-Hoon Ahn1* Drug Discovery Platform Technology Team, Korea Research Institute of Chemical Technology, Daejeon 305-600, Republic of Korea, Department of Pharmaceutics, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea, and Medicinal Chemistry Research Center, Korea Research Institute of Chemical Technology, Daejeon 305-600, Republic of Korea