Association between Paraoxonase 1 polymorphisms and risk of esophagogastric junction adenocarcinoma: a case-control study involving 2,740 subjects

// Weifeng Tang 1, * , Jianchao Liu 1, * , Yafeng Wang 2 , Yanchao Chen 3 , Mingqiang Kang 4, 5, 6 , Jun Yin 1 , Chao Liu 1 , Jing Lin 7 and Yu Chen 7, 8, 9 1 Department of Cardiothoracic Surgery, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China 2 Department of Cardiology, The People’s Hospital of Xishuangbanna Dai Autonomous Prefecture, Jinghong, Yunnan Province, China 3 Department of Thoracic Surgery, Affiliated Jurong People’s Hospital of Jiangsu University, Jurong, Jiangsu Province, China 4 Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China 5 Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou, Fujian Province, China 6 Fujian Key Laboratory of Tumor Microbiology, Fujian Medical University, Fuzhou, Fujian Province, China 7 Department of Medical Oncology, Fujian Cancer Hospital and Fujian Medical University Cancer Hospital, Fuzhou, Fujian Province, China 8 Cancer Bio-immunotherapy Center, Fujian Cancer Hospital and Fujian Medical University Cancer Hospital, Fuzhou, Fujian Province, China 9 Fujian Provincial Key Laboratory of Translational Cancer Medicine, Fuzhou, Fujian Province, China * These authors contributed equally to this work Correspondence to: Weifeng Tang, email: twf001001@126.com Yu Chen, email: 13859089836@139.com Keywords: PON1, polymorphism, esophagogastric junction adenocarcinoma Received: June 11, 2017      Accepted: July 25, 2017      Published: August 10, 2017 ABSTRACT Esophagogastric junction adenocarcinoma (EGJA) is a serious public health problem with high mortality in China. In this study, we assessed the association between Paraoxonase 1 ( PON-1 ) rs662 C>T, rs854560 A>T polymorphisms and EGJA risk. This case-control study enrolled 2,740 participants of Asians origin from the Eastern Chinese Han populations. SNPscanTM genotyping assay was harnessed to determine the genotyping of PON1 polymorphisms. The PON-1 rs854560 A>T and rs662 C>T genotypes distribution accorded with Hardy–Weinberg equilibrium. We found that there was no difference in the frequency of PON-1 rs662 C>T, rs854560 A>T genotypes between the overall EGJA cases and controls. In the subgroup analyses, the results indicated that PON-1 rs662 C>T polymorphism might be associated with a significantly decreased risk of EGJA in ever smoking group (TT vs. CC/CT: adjusted OR = 0.58, 95% CI 0.35–0.95, P = 0.029). In conclusion, our study highlights PON-1 rs662 C>T polymorphism may decrease the risk of EGJA, which interacts with the tobacco using. In the future, a fine-mapping case-control study with detailed gene-environmental data is needed to further assess these potential relationship.