Исследование фармакокинетики препарата проспидин при внутрипузырном введении экспериментальным животным

The pharmacokinetics of anticancer drug prospidine in intact rats has been studied upon intravesical administration at a dose of 100 mg/kg. It is established that the maximum concentration of the drug with specific radioactivity 10 μCurie 14 C per 10 mg in the systemic circulation is achieved in 10 min after introduction and amounts to 140 μg/mL. After 2 h, prospidine was present in the plasma in trace amounts.