Characteristics of inspiratory and expiratory reactance in interstitial lung disease

Summary Background: Forced oscillometry is a non-invasive method to measure respiratory resistance and reactance. In this study, we investigated the characteristics of measurements obtained with an impulse oscillation system (IOS) for patients with interstitial lung disease (ILD). Method: IOS and spirometry were performed in 64 ILD patients, 54 asthma patients, 49 chronic obstructive pulmonary disease (COPD) patients, and 29 controls. Respiratory resistance and reactance were assessed as measurements averaged over several tidal breaths (whole-breath analysis) and as measurements separately averaged during inspiration and expiration (inspiratoryeexpiratory analysis). Results: Whole-breath IOS analyses for ILD patients showed increased resistance at 5 Hz and decreased reactance at 5 Hz (X5) compared with controls, although these features were also found in asthma and COPD patients. Inspiratoryeexpiratory analysis demonstrated that the changes in X5 and reactance area (AX) between inspiration and expiration (DX5 and DAX, respectively) were significantly different from those in asthma patients, COPD patients, and controls. However, multiple linear regression analysis showed that the presence of ILD was independently associated with DX5, but not with DAX. Furthermore, DX5 was inversely correlated with vital capacity and diffusing capacity of carbon monoxide in ILD patients. Conclusions: Our results suggest that DX5 is a characteristic feature of IOS measurements in ILD patients, which is clearly different from those in asthma and COPD patients. This withinbreath X5 change in ILD might be associated with its severity and physiological abnormality, although further studies are needed to investigate its cause.