METASTATIC ORAL MELANOMA: A CASE REPORT

Oral melanoma represents an unusual type of malignant tumor that is extremely aggressive, with poor prognosis that usually develops distant metastases, local recurrence, and low overall survival in 5 years. A 66-year-old female patient, ex-smoker, complained of palate lesion after a dental procedure 1 year ago, weight loss of 10 kg in 6 months, and cervical lymphadenopathy. The oroscopy evidenced a bleeding blackened lesion of approximately 10 cm located on the palate, affecting left gingival border and ipsilateral lymphadenopathy. Incisional biopsy was performed with a positive result for invasive melanoma and positive immunohistochemical profile for HMB-45, Melan-A, and S-100. Thorax tomography presented suspect image of secondary involvement, and clinical staging was defined as T4 BN1 M1, grade IVb. Surgical treatment was contraindicated due to metastatic lesions. Oncologists are waiting the result of c-Kit for therapeutic definition.