Epidemic Trend of Influenza and COVID-19 in Children from 2019 Winter to 2020 Spring: A Cross-sectional Analysis in Wuhan Children's Hospital/ 2019—2020年冬春季武汉儿童医院收治流感和新型冠状病毒肺炎患儿的流行病学特点

Objective: To study the epidemiological characteristics of influenza (A & B) and SARS-CoV-2 infection in children from 2019 winter to 2020 spring in Wuhan Children's Hospital, and to provide data support for scientific prevention and efficient decision- making Methods: We collected the data of suspected and confirmed cases of influenza and Corona Virus Disease 2019 (COVID-19) from Wuhan Children Hospital during 11/1/2019 to 2/29/ 2020 and analyzed the case distributions by age groups, genders, date of diagnosis and regions Results: We enrolled 44 038 influenza-like cases, and the total number of male cases (accounted for 56 39%) were higher than that of female (accounted for 43 61%) Statistical significant differences in case numbers were observed between different genders and age groups (X2 = 40 990, P<0 001) T FI proportion of children at the age of 6 to 10 years old were the largest in all age groups All of 7311 confirmed influenza cases included 77 8% influenza A cases, which was higher than the influenza B cases with the ratio of 22 2% The difference between them was statistically significant (X2=40 172, P<0 001) Most influenza A (37 97%) and B (25 39%) cases were found in children aged 6-10 years old And the number of confirmed influenza B cases among different gender and age groups were statistically different;and male cases were more than female cases (X2= 15 009, P=0 010) In the meanwhile, we collected 482 COVID-19-like cases (including suspected and confirmed cases) from the hospital Children aged from 29 days to 1-year-old accounted for the largest proportion The majority of 221 confirmed cases were children aged 6-10-year-old (39 60%), but the number of cases in different ages was not significant The top five distribution regions of confirmed COVID-19 cases were Hongshan district (16 29 %), Hanyang district (12 67%), Jiangan District (11 76%), Qiaokou district (9 95%) and Wuchang district (9 05%) Conclusion: The number of influenza- like cases in children aged 6-10-year-old was the highest, and the incidence of the infection in males is higher than that in females The current focus of the prevention and control in children is still influenza A Children in different ages and genders were generally susceptible to the SARS-CoV-2 infection And children at the age of 6to 10 years old were the main population in influenza virus and SARS-CoV-2 infection Effective measures should be taken in urban areas with high population density to prevent the infection of SARS-CoV-2