In Vivo Uptake and Processing of Liposomes by Parenchymal and Non-Parenchymal Liver Cells; Application to Immunotherapeutic Treatment of Hepatic Metastases

Many early investigations on the in vivo fate of intravenously injected liposomes have pointed to the liver as the major organ responsible for elimination from the circulatory system. For several years now we have made detailed studies on the participation of various cell types of the liver, mainly macrophages and hepatocytes, in the hepatic uptake and processing of liposomes, both in vivo and in vitro.