A murine macrofilaricide pre-clinical screening model for onchocerciasis and lymphatic filariasis
2014
Background
New drugs effective against adult filariae (macrofilaricides) would accelerate the elimination of lymphatic filariasis and onchocerciasis. Anti-Onchocerca drug development is hampered by the lack of a facile model. We postulated that SCID mice could be developed as a fmacrofilaricide screening model.
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