Experimental Therapies Of Human Pancreatic Carcinoma Transplanted To Nude Mice - A Study On Photodynamic Therapy And Local Interstitial Hyperthermia Using Low Power Nd:YAG Laser

* Department of Internal Medicine, National Cancer Center Hospital, Tokyo, Japan.** Surgical Laser Technologies, Inc., Tokyo, Japan.* ** Department of Surgery, University of Cincinnati Medical Center, Cincinnati, Ohio,U.S.A.AbstractWe have used photodynamic therapy (PDT) and local interstitial hyperthermia with lowpower Nd:YAG laser in nude mice in an attempt to study their therapeutic effects forfurther investigation. Pieces of solid tumor of human pancreatic carcinoma were subcutan-eously transplanted in the backs of 28 nude mice which are 5 -weeks old female. The fllow-ing experimental therapies were begun 5 -6 weeks after the transplantation. 1) PDT:Argon dyelaser was irradiated into a tumor with 300 -400 mW in 72 hours after hematoporphyrine deriva-tive (HpD) in a dose of 3 mg /kg was intravenously injected. Histological changes detectedafter 7 days were coagulated necrosis and fibrosis in the tissues ranging from 30 to 50%area ratio.