Protective role of cyclooxygenase (COX) inhibitors in burn-induced intestinal and liver damage

Abstract The aim of this study was to investigate the role of cyclooxygenase (COX) inhibition in intestinal motility and in the extent of tissue injury of the small intestine and liver with the use of various COX inhibitors. Wistar albino rats were exposed to 90 °C water bath for 10 s. The intestinal transit index decreased compared to control group and treatment with nimesulide (NIM; 10 mg/kg, subcutaneously) or piroxicam (Pir; 5 mg/kg, orogastrically) reversed this effect significantly. The intestinal and liver glutathione levels showed a significant decrease in the burn group compared to sham ( P P P P P P P