The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective α7 nicotinic receptor partial agonist

Abstract The 5-HT 3 receptor antagonist tropisetron (ICS 205-930) was found to be a potent and selective partial agonist at α7 nicotinic receptors. Two other 5-HT 3 receptor antagonists, ondansetron and LY-278,584, were found to lack high affinity at the α7 nicotinic receptor. Quinuclidine analogues ( 1 and 2 ) of tropisetron were also found to be potent and selective partial agonists at α7 nicotinic receptors.