COMBINED APPROACH TO PROTEIN SECONDARY STRUCTURE PREDICTION

Summary Motivation: The most important achievements in protein secondary structure prediction are based on two different approaches. The first one is the statistical approach and the second one is the physical-chemical approach. In the first approach we analyze appearance of different types of amino acids in given conformations. The second approach use conformational calculations and physical-chemical properties of a given molecule. Presently these approaches are developed independently. The creation of the method, which will contain advantages of the statistical and the physical-chemical approaches, is very important task. Results: We have developed the new approach for secondary structure prediction. Using our combined approach one can obtain the secondary structure of a given protein from its primary structure only. The base of our method is a joint using advantages provided by conformational calculations, data on primary structure and physical-chemical properties of proteins. For the combined approach to be demonstrated, we have predicted the protein secondary structure of four basic types: α-helix, helix 3/10, coil, and turn using only sequences of given proteins from Protein Data Bank.