GProteinβ3SubunitPolymorphismandLong-TermPrognosisofFunctional Dyspepsia

Background/Aims: A link between G protein β3 (GNB3) polymorphism and functional dyspepsia (FD) has been sug- gested. The aim of this study was to determine the role of GNB3 polymorphism in the long-term prognosis of FD in Koreans. Methods: FD patients and normal healthy controls were recruited from patients who visited our center between December 2006 and June 2007. All of the subjects complet- ed Rome III questionnaires before undergoing upper gastro- intestinal endoscopy and colonoscopy. Genomic DNA was ex- tracted for GNB3 genotyping. After 5 years, the subjects were reevaluated using the same questionnaires. Results: GNB3 825T carrier status was significantly related to FD in Koreans (p=0.04). After 5 years, 61.0% of the initial FD patients and 12.2% of the initial normal subjects were diagnosed with FD (odds ratio (OR), 11.7; 95% confidence interval (CI), 4.3 to 31.1; p<0.001). Regardless of the GNB3 genotype (p=0.798), female sex was strongly correlated with FD after 5 years (OR, 3.3; 95% CI, 1.2 to 9.1; p=0.017). Conclusions: The T allele of GNB3 is linked to FD in Koreans but does not predict long- term prognosis. Female sex is related to a higher prevalence of FD after 5 years. (Gut Liver 2014;8:271-276)