INTERLEUKIN-1 BLOCKADE IMPROVES LEFT VENTRICULAR PERFORMANCE IN DECOMPENSATED HEART FAILURE WITHOUT INCREASING MYOCARDIAL WORK

Interleukin-1 (IL-1) is a cytokine that acts as a soluble cardiodepressant during acute inflammatory conditions. We hypothesized that, in patients with acute decompensated heart failure (ADHF), IL-1 blockade would improve left ventricular (LV) systolic performance without increasing myocardial